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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
56.97
Human Site:
Y76
Identified Species:
78.33
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Chimpanzee
Pan troglodytes
XP_523824
217
24938
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
Y112
V
E
D
F
W
A
L
Y
S
H
I
Q
L
A
S
Dog
Lupus familis
XP_544992
217
25075
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
Y104
V
E
D
F
W
A
V
Y
S
H
I
K
L
A
S
Rat
Rattus norvegicus
P63074
217
25035
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
T85
T
E
T
S
Q
E
V
T
N
P
E
H
Y
I
K
Chicken
Gallus gallus
XP_420655
217
25026
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Frog
Xenopus laevis
P48597
213
24616
Y72
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
Y74
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
Y120
V
E
D
F
W
S
L
Y
N
H
I
K
P
P
S
Honey Bee
Apis mellifera
XP_624290
213
24784
Y72
A
E
D
F
W
S
L
Y
N
H
I
K
A
A
S
Nematode Worm
Caenorhab. elegans
O61955
248
27791
A77
L
Y
N
H
I
Q
S
A
G
G
L
N
W
G
S
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
Y84
V
E
D
F
W
A
L
Y
N
H
I
Q
V
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
Y85
V
E
E
F
W
G
L
Y
N
N
I
N
H
P
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
Y102
V
E
E
F
W
S
L
Y
N
N
M
K
H
P
S
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
I78
V
E
E
F
W
A
I
I
Q
N
I
P
E
P
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
86.6
100
N.A.
73.3
100
N.A.
13.3
100
100
100
N.A.
73.3
66.6
6.6
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
100
100
N.A.
86.6
86.6
26.6
100
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
60
N.A.
53.3
40
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
86.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
0
0
0
65
0
6
0
0
0
0
6
24
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
71
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
95
18
0
0
6
0
0
0
0
6
0
6
0
0
% E
% Phe:
0
0
0
89
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
6
0
0
6
6
0
0
0
6
0
% G
% His:
0
0
0
6
0
0
0
0
0
71
0
6
12
0
6
% H
% Ile:
0
0
0
0
6
0
6
6
0
0
83
0
0
6
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
24
0
0
6
% K
% Leu:
6
0
0
0
0
0
77
0
0
0
6
0
53
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% M
% Asn:
0
0
6
0
0
0
0
0
77
18
0
12
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
6
0
6
6
24
0
% P
% Gln:
0
0
0
0
6
6
0
0
6
0
0
53
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
6
0
18
6
0
12
0
0
0
0
42
89
% S
% Thr:
6
0
6
0
0
0
0
6
0
0
0
0
0
0
0
% T
% Val:
83
0
0
0
0
0
12
0
0
0
0
0
6
0
0
% V
% Trp:
0
0
0
0
89
0
0
0
0
0
0
0
6
0
0
% W
% Tyr:
0
6
0
0
0
0
0
83
0
0
0
0
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _